Products 162011-90-7
CAS 162011-90-7 appears in our catalog under these names: Rofecoxib, Vioxx, >95% (HPLC), Rofecoxib, >98.0%(GC), Rofecoxib - Bio-X â„¢, Rofecoxib, 99.00%. Offered by: Chemat Brand, TRC, GLPBio, TCI, Biosynth. Available pack sizes: on request, 100mg, 10mg, 250mg, 10mM (in 1ml dmso), 1g, 10g, 5g.
Rofecoxib is a butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke. It has a role as a non-steroidal anti-inflammatory drug, an analgesic and a cyclooxygenase 2 inhibitor. It is a sulfone and a butenolide.
Source: ChEBI
| Molecular formula | C17H14O4S |
|---|---|
| Molecular weight | 314.4 g/mol |
| IUPAC name | 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one |
| InChIKey | RZJQGNCSTQAWON-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3 |
Computed by PubChem (NCBI)
Synonyms:
rofecoxib, Vioxx, Ceoxx, 4-(4-(Methylsulfonyl)phenyl)-3-phenylfuran-2(5H)-one, 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one, Vioxx Dolor, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone, rofecoxibum, 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone, 4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone