Products 164650-44-6

CAS 164650-44-6 appears in our catalog under these names: Efinaconazole, Efinaconazole, >95% (HPLC), Efinaconazole/ 99.7% (existing batch purity), Efinaconazole, 98+%, (αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol, 98%, 98%. Offered by: Chemat Brand, TRC, Dr. Ehrenstorfer, TargetMol, GLPBio. Available pack sizes: on request, 100mg, 1mg, 50mg, 25mg, 5mg, 10mg, 500mg.

Efinaconazole
Chemat Brand, Dr. Ehrenstorfer, GLPBio
  • size: on request, 25mg, 10mg, 100mg
  • Variants: 13
from 657.89
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Efinaconazole, >95% (HPLC)
TRC
  • size: 100mg, 1mg, 50mg
  • Variants: 3
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Efinaconazole/ 99.7% (existing batch purity)
TargetMol
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 6
from 465.53
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Efinaconazole, 98+%
Thermo Scientific (Acros)
  • size: 100MG
  • Variants: 1
from 2115.86
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(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol, 98%, 98%
Chemat
  • size: 25mg, 100mg, 250mg, 1g
  • Variants: 8
from 102.80
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Efinaconazole, 99.84%
MedChemExpress
  • size: 10mM/1mL, 50 mg, 5 mg, 10 mg
  • Variants: 5
from 384.71
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Efinaconazole, 250 mg
Roth
  • size: 250mg
  • Variants: 1
from 1033.60
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Efinaconazole, 500 mg
Roth
  • size: 500mg
  • Variants: 1
from 1505.56
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Efinaconazole, 1 g
Roth
  • size: 1g
  • Variants: 1
from 2543.87
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Efinaconazole, 2 g
Roth
  • size: 2g
  • Variants: 1
from 4006.94
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(2R,3R)-2-(2,4-DIFLUOROPHENYL)-3-(4-METHYLENEPIPERIDIN-1-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL, 97%
Fluorochem
  • size: 25mg, 100mg, 250mg, 1g
  • Variants: 5
from 268.67
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Structural formula: {0} (CAS {1})

Efinaconazole is a member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes). It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. It is a member of piperidines, a tertiary alcohol, an organofluorine compound, a tertiary amino compound, an olefinic compound, a conazole antifungal drug and a triazole antifungal drug.

Source: ChEBI

Identity
Molecular formulaC18H22F2N4O
Molecular weight348.4 g/mol
IUPAC name(2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
InChIKeyNFEZZTICAUWDHU-RDTXWAMCSA-N
SMILESC[C@H]([C@](CN1C=NC=N1)(C2=C(C=C(C=C2)F)F)O)N3CCC(=C)CC3

Computed by PubChem (NCBI)

Synonyms: EFINACONAZOLE, JUBLIA, efinaconazol, Clenafin, Kp 103, efinaconazolum, Efinaconazole [INN], Efinaconazole [USAN:INN], Clenafin (TN), Jublia (TN)
Related forms of this compound
(2R,3S)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol C18H22F2N4O
(2S,3R)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol C18H22F2N4O
(2S,3S)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol C18H22F2N4O
Isomers (same molecular formula)
(2R,3R)-6-fluoro-2-methyl-4'-methylidene-3-(1,2,4-triazol-1-ylmethyl)spiro[2H-indol-1-ium-1,1'-azinan-1-ium]-3-ol fluoride C18H22F2N4O
(2R,3R)-2-(2,4-difluorophenyl)-3-(4-methyl-3,6-dihydro-2H-pyridin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol C18H22F2N4O
(2R,3R)-2-(2,4-difluorophenyl)-3-(3-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol C18H22F2N4O