Products 877399-52-5

CAS 877399-52-5 appears in our catalog under these names: Crizotinib, (R)–Crizotinib, Crizotinib/ 99.35% (existing batch purity), Crizotinib - Bio-X â„¢, Crizotinib, 98.00%. Offered by: Chemat Brand, Mikromol, GLPBio, TargetMol, Biosynth. Available pack sizes: on request, 250mg, 10mg, 100mg, 10mM (in 1ml dmso), 50mg, 25mg, 200mg.

Crizotinib
Chemat Brand, Mikromol, Biosynth
  • size: on request, 250mg, 0,25g, 0,1g
  • Variants: 9
from 668.17
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(R)–Crizotinib
GLPBio
  • size: 10mg, 100mg, 10mM (in 1ml dmso), 50mg
  • Variants: 4
from 564.28
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Crizotinib/ 99.35% (existing batch purity)
TargetMol
  • size: 10mg, 25mg, 50mg, 100mg
  • Variants: 6
from 485.65
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Crizotinib - Bio-X â„¢
Biosynth
  • size: 10mg
  • Variants: 1
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Crizotinib, 98.00%
Chemat
  • size: 10mg
  • Variants: 1
from 876.03
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Crizotinib 98%
Ambeed
  • size: 1mg, 10mg, 25mg, 100mg
  • Variants: 8
from 175.69
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Crizotinib, min. 95 %, 100 mg
Roth
  • size: 100mg
  • Variants: 1
from 1127.99
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Crizotinib, min. 95 %, 250 mg
Roth
  • size: 250mg
  • Variants: 1
from 1599.95
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Crizotinib, min. 95 %, 500 mg
Roth
  • size: 500mg
  • Variants: 1
from 2383.40
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Crizotinib, min. 95 %, 1 g
Roth
  • size: 1g
  • Variants: 1
from 3516.11
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Crizotinib, min. 95 %, BioScience Grade, 10 mg
Roth
  • size: 10mg
  • Variants: 1
from 514.44
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Crizotinib, 99.97%
MedChemExpress
  • size: 500 mg, 5 mg, 100 mg, 10mM/1mL
  • Variants: 7
from 287.18
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Crizotinib (Standard)
MedChemExpress
  • size: 10 mg, 50 mg, 100 mg, 5 mg
  • Variants: 5
from 542.60
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Crizotinib, 95%
Fluorochem
  • size: 1g, 5g, 25g
  • Variants: 3
from 263.47
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Structural formula: {0} (CAS {1})

Crizotinib is a 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). It has a role as an antineoplastic agent, a biomarker and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is an enantiomer of an ent-crizotinib.

Source: ChEBI

Identity
Molecular formulaC21H22Cl2FN5O
Molecular weight450.3 g/mol
IUPAC name3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
InChIKeyKTEIFNKAUNYNJU-GFCCVEGCSA-N
SMILESC[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Computed by PubChem (NCBI)

Synonyms: Crizotinib, (R)-crizotinib, Xalkori, crizotinibum, MET Tyrosine Kinase Inhibitor PF-02341066, Crizotinib (PF-02341066), CRIZOTINIB [MART.], Crizotinib (PF-2341066), C21H22Cl2FN5O, VGH
Related forms of this compound
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(3,3,4,5,5-pentadeuteriopiperidin-4-yl)pyrazol-4-yl]pyridin-2-amine C21H22Cl2FN5O
3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine C21H22Cl2FN5O
Isomers (same molecular formula)
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine C21H22Cl2FN5O