Products 917879-39-1
CAS 917879-39-1 appears in our catalog under these names: MK-2461, MK-2461/ 99.53% (existing batch purity), MK–2461, N-[(2R)-1,4-Dioxan-2-ylmethyl]-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide, 98%, 98%, MK-2461, 99.28%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Chemat. Available pack sizes: 100mg, 1mg, 5mg, 10mg, 25mg, 50mg, 10mM (in 1ml dmso), 200mg.
MK-2461 is a member of the class of benzocycloheptapyridines that is 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one substituted by 1-methyl-1H-pyrazol-4-yl and [{[(2R)-1,4-dioxan-2-yl]methyl}(methyl)sulfamoyl]amino groups at positions 3 and 7, respectively. It is a novel ATP-competitive multi-targeted inhibitor of activated c-Met (IC50 = 2.5 nM). It has a role as an antineoplastic agent, an apoptosis inducer and a c-Met tyrosine kinase inhibitor. It is a member of pyrazoles, a member of dioxanes, a benzocycloheptapyridine and a member of sulfamides.
Source: ChEBI
| Molecular formula | C24H25N5O5S |
|---|---|
| Molecular weight | 495.6 g/mol |
| IUPAC name | 14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene |
| InChIKey | JGEBLDKNWBUGRZ-HXUWFJFHSA-N |
| SMILES | CN1C=C(C=N1)C2=CC3=C(C=CC4=C(C3=O)C=C(C=C4)NS(=O)(=O)N(C)C[C@@H]5COCCO5)N=C2 |
Computed by PubChem (NCBI)