Products 937272-79-2
CAS 937272-79-2 appears in our catalog under these names: Pacritinib, Pacritinib (SB1518), Pacritinib/ 99.52% (existing batch purity), Pacritinib 97%, (16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 97%, 97%. Offered by: TRC, GLPBio, TargetMol, Biosynth, Ambeed. Available pack sizes: 200mg, 10mg, 25mg, 5mg, 10mM (in 1ml dmso), 50mg, 2mg, 100mg.
Pacritinib is an azamacrocycle with formula C28H32N4O3. It is a Janus kinase inhibitor and its citrate salt is approved for the treatment of intermediate or high risk, primary or secondary myelofibrosis. It has a role as an antineoplastic agent, an anti-inflammatory agent, an apoptosis inducer and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a member of benzenes, a cyclic ether, a member of pyrrolidines and an azamacrocycle. It is a conjugate base of a pacritinib(1+).
Source: ChEBI
| Molecular formula | C28H32N4O3 |
|---|---|
| Molecular weight | 472.6 g/mol |
| IUPAC name | (16E)-11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(24),2(27),3,5,8(26),9,11,16,21(25),22-decaene |
| InChIKey | HWXVIOGONBBTBY-ONEGZZNKSA-N |
| SMILES | C1CCN(C1)CCOC2=C3COC/C=C/COCC4=CC(=CC=C4)C5=NC(=NC=C5)NC(=C3)C=C2 |
Computed by PubChem (NCBI)