Products 157-03-9
CAS 157-03-9 appears in our catalog under these names: H-L-Don-OH, 6-Diazo-5-oxo-L-norleucine, >95% (HPLC), 6-Diazo-5-oxo-L-nor-Leucine/ 98.48% (existing batch purity), 6–diazo–5–oxo–L–nor–Leucine, 6-DIAZO-5-OXO-L-NORLEUCINE. Offered by: Creative Peptides, TRC, TargetMol, GLPBio, Sigma-Aldrich. Available pack sizes: on request, 10mg, 1mg, 5mg, 25mg, 50mg, 100mg, 10 mg.
6-diazo-5-oxo-L-norleucine is a non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes. It has a role as an EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor, an EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor, an EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor, an EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor, a glutamine antagonist, an EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor, an EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor, an EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor, an antiviral agent, an antibacterial agent, an antimetabolite, an analgesic, an antineoplastic agent, an EC 3.5.1.2 (glutaminase) inhibitor, an apoptosis inducer and a bacterial metabolite. It is a ketone, a diazo compound and a non-proteinogenic L-alpha-amino acid. It is a tautomer of a 6-diazo-5-oxo-L-norleucine zwitterion.
Source: ChEBI
| Molecular formula | C6H9N3O3 |
|---|---|
| Molecular weight | 171.15 g/mol |
| IUPAC name | (2S)-2-amino-6-diazo-5-oxohexanoic acid |
| InChIKey | YCWQAMGASJSUIP-YFKPBYRVSA-N |
| SMILES | C(CC(=O)C=[N+]=[N-])[C@@H](C(=O)O)N |
Computed by PubChem (NCBI)