7-Ethyl-10-hydroxycamptothecin, 97%

cas: 86639-52-3 — see every product listed under this CAS number, including other names

7-Ethyl-10-hydroxycamptothecin, 97% (CAS 86639-52-3) is a chemical reagent available from Chemat. Available pack sizes: 10g, 5g, 25g, 1g. Offered by: Combi-blocks.

brandCombi-blocks
catalog numberST-6573-10g
cas86639-52-3
size10g
Documents: Safety Data Sheet (MSDS)
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Available pack sizes

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properties

purity97%
delivery time1-2 weeks (only if in stock, to check click on availability)
Structural formula: {0} (CAS {1})

SN-38 is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an antineoplastic agent, a drug metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an apoptosis inducer. It is a delta-lactone, a tertiary alcohol, a member of phenols and a pyranoindolizinoquinoline.

Source: ChEBI

Identity
Molecular formulaC22H20N2O5
Molecular weight392.4 g/mol
IUPAC name(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
InChIKeyFJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILESCCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O

Computed by PubChem (NCBI)

Synonyms: 7-Ethyl-10-hydroxycamptothecin, 10-Hydroxy-7-ethylcamptothecin, 7-Ethyl-10-hydroxy-20(S)-camptothecin, 7 Ethyl 10 hydroxycamptothecin, 7-Ethyl-10-hydroxy-camptothecin, 7-10-hydroxycamptothecin, Irinotecan EP Impurity E, Captothecin, 7-ethyl-10-hydroxy-, AvaChem1025, diethyl(dihydroxy)[?]dione
Related forms of this compound
(19S)-19-ethyl-7,19-dihydroxy-10-(2,2,2-trideuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
(19R)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
(19S)-19-ethyl-7,19-dihydroxy-10-(1,1,2,2,2-pentadeuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
Isomers (same molecular formula)
(19S)-10,19-diethyl-19-hydroxy-3-oxido-17-oxa-13-aza-3-azoniapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione C22H20N2O5
methyl 1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate C22H20N2O5
methyl (1R,3R)-2-acetyl-1-(1,3-benzodioxol-5-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate C22H20N2O5
(19S)-5,19-diethyl-8,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione C22H20N2O5
4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione C22H20N2O5

Also listed as

Irinotecan EP Impurity E ((S)-7-Ethyl-10-Hydroxy Camptothecin) Chemat Brand CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin ((S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione) Mikromol CAS 86639-52-3
SN-38, >95% (HPLC) TRC CAS 86639-52-3
SN–38 (NK012) GLPBio CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin Biosynth CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, >98.0%(HPLC) TCI CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, 98% Thermo Scientific (Acros) CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, 98.00% Chemat CAS 86639-52-3
SN-38 98% Ambeed CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, min. 95 %, 1 g Roth CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, min. 95 %, 5 g Roth CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, min. 95 %, 10 g Roth CAS 86639-52-3
SN-38, 99.94% MedChemExpress CAS 86639-52-3
SN-38 (Standard), 99.76% MedChemExpress CAS 86639-52-3
7-Ethyl-10-hydroxy-camptothecin, 98% Fluorochem CAS 86639-52-3