SN-38 (Standard), 99.76%
cas: 86639-52-3 — see every product listed under this CAS number, including other names
SN-38 (Standard), 99.76% (CAS 86639-52-3) is a chemical reagent available from Chemat. Available pack sizes: 50 mg, 100 mg, 25 mg, 10 mg, 5 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-13704R-50 mg |
| cas | 86639-52-3 |
| size | 50 mg |
| availability | In stock |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 50 mg | 960.56 Pln | |
| MedChemExpress | 100 mg | 1383.17 Pln | |
| MedChemExpress | 25 mg | 681.92 Pln | |
| MedChemExpress | 10 mg | 431.15 Pln | |
| MedChemExpress | 5 mg | 324.34 Pln |
properties
| delivery time | 1-2 weeks |
|---|---|
| purity | 99.76% |
SN-38 is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an antineoplastic agent, a drug metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an apoptosis inducer. It is a delta-lactone, a tertiary alcohol, a member of phenols and a pyranoindolizinoquinoline.
Source: ChEBI
| Molecular formula | C22H20N2O5 |
|---|---|
| Molecular weight | 392.4 g/mol |
| IUPAC name | (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione |
| InChIKey | FJHBVJOVLFPMQE-QFIPXVFZSA-N |
| SMILES | CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O |
Computed by PubChem (NCBI)
Synonyms:
7-Ethyl-10-hydroxycamptothecin, 10-Hydroxy-7-ethylcamptothecin, 7-Ethyl-10-hydroxy-20(S)-camptothecin, 7 Ethyl 10 hydroxycamptothecin, 7-Ethyl-10-hydroxy-camptothecin, 7-10-hydroxycamptothecin, Irinotecan EP Impurity E, Captothecin, 7-ethyl-10-hydroxy-, AvaChem1025, diethyl(dihydroxy)[?]dione