SN-38, 99.94%

cas: 86639-52-3 — see every product listed under this CAS number, including other names

SN-38, 99.94% (CAS 86639-52-3) is a chemical reagent available from Chemat. Available pack sizes: 10mM/1mL, 500 mg, 1 g, 50 mg, 200 mg, 100 mg. Offered by: MedChemExpress.

brandMedChemExpress
catalog numberHY-13704-10mM/1mL
cas86639-52-3
size10mM/1mL
availability Get quote
Need more information?

Ask us about this product — we're happy to help.

Available pack sizes

brand size price
MedChemExpress 10mM/1mL 491.52 Pln
MedChemExpress 500 mg 983.78 Pln
MedChemExpress 1 g 1243.85 Pln
MedChemExpress 50 mg 454.37 Pln
MedChemExpress 200 mg 765.52 Pln
MedChemExpress 100 mg 579.76 Pln

properties

delivery time over 3 weeks
purity99.94%
Structural formula: {0} (CAS {1})

SN-38 is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an antineoplastic agent, a drug metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an apoptosis inducer. It is a delta-lactone, a tertiary alcohol, a member of phenols and a pyranoindolizinoquinoline.

Source: ChEBI

Identity
Molecular formulaC22H20N2O5
Molecular weight392.4 g/mol
IUPAC name(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
InChIKeyFJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILESCCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O

Computed by PubChem (NCBI)

Synonyms: 7-Ethyl-10-hydroxycamptothecin, 10-Hydroxy-7-ethylcamptothecin, 7-Ethyl-10-hydroxy-20(S)-camptothecin, 7 Ethyl 10 hydroxycamptothecin, 7-Ethyl-10-hydroxy-camptothecin, 7-10-hydroxycamptothecin, Irinotecan EP Impurity E, Captothecin, 7-ethyl-10-hydroxy-, AvaChem1025, diethyl(dihydroxy)[?]dione
Related forms of this compound
(19S)-19-ethyl-7,19-dihydroxy-10-(2,2,2-trideuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
(19R)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
(19S)-19-ethyl-7,19-dihydroxy-10-(1,1,2,2,2-pentadeuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
Isomers (same molecular formula)
(19S)-10,19-diethyl-19-hydroxy-3-oxido-17-oxa-13-aza-3-azoniapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione C22H20N2O5
methyl 1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate C22H20N2O5
methyl (1R,3R)-2-acetyl-1-(1,3-benzodioxol-5-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate C22H20N2O5
(19S)-5,19-diethyl-8,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione C22H20N2O5
4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione C22H20N2O5

Also listed as

7-Ethyl-10-hydroxycamptothecin, 97% Combi-blocks CAS 86639-52-3
Irinotecan EP Impurity E ((S)-7-Ethyl-10-Hydroxy Camptothecin) Chemat Brand CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin ((S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione) Mikromol CAS 86639-52-3
SN-38, >95% (HPLC) TRC CAS 86639-52-3
SN–38 (NK012) GLPBio CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin Biosynth CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, >98.0%(HPLC) TCI CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, 98% Thermo Scientific (Acros) CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, 98.00% Chemat CAS 86639-52-3
SN-38 98% Ambeed CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, min. 95 %, 1 g Roth CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, min. 95 %, 5 g Roth CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, min. 95 %, 10 g Roth CAS 86639-52-3
SN-38 (Standard), 99.76% MedChemExpress CAS 86639-52-3
7-Ethyl-10-hydroxy-camptothecin, 98% Fluorochem CAS 86639-52-3

Related products in this category

Balofloxacin (Standard) MedChemExpress CAS 127294-70-6
Lafutidine, 99.56% MedChemExpress CAS 118288-08-7
Lafutidine (Standard) MedChemExpress CAS 118288-08-7
Duloxetine, 99.92% MedChemExpress CAS 116539-59-4
Duloxetine (hydrochloride), 99.97% MedChemExpress CAS 136434-34-9
Duloxetine (hydrochloride) (Standard) MedChemExpress CAS 136434-34-9
(R)-Duloxetine MedChemExpress CAS 116539-60-7
(R)-Duloxetine (hydrochloride) MedChemExpress CAS 910138-96-4
(±)-Duloxetine (hydrochloride) MedChemExpress CAS 947316-47-4