AZD1080, 98+%, 98+%

cas: 612487-72-6 — see every product listed under this CAS number, including other names

AZD1080, 98+%, 98+% (CAS 612487-72-6) is a chemical reagent available from Chemat. Available pack sizes: 1mg, 2mg, 5mg, 10mg. Offered by: Chemat.

brandChemat
catalog numberCh114EEI-1mg
cas612487-72-6
size1mg
availability 0.05g
Need more information?

Ask us about this product — we're happy to help.

Available pack sizes

brand size price
Chemat 1mg 112.40 Pln
Chemat 2mg 136.40 Pln
Chemat 5mg 150.80 Pln
Chemat 10mg 170.00 Pln

properties

purity98+%
delivery time3 weeks
Structural formula: {0} (CAS {1})

AZD1080 is a member of the class of hydroxyindoles that is 1H-indole substituted by hydroxy, 5-(morpholin-4-ylmethyl)pyridin-2-yl, and cyano groups at positions 2, 3 and 5, respectively. It is a potent, brain permeable inhibitor of human GSK3alpha and GSK3beta with Ki of 6.9 nM and 31 nM, respectively. The drug was being developed by AstraZeneca for the treatment of Alzheimer's disease (clinical trial now discontinued). It has a role as a tau aggregation inhibitor, an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a nitrile, a member of pyridines, a member of morpholines, a tertiary amino compound and a member of hydroxyindoles.

Source: ChEBI

Identity
Molecular formulaC19H18N4O2
Molecular weight334.4 g/mol
IUPAC name2-hydroxy-3-[5-(morpholin-4-ylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile
InChIKeyBLTVBQXJFVRPFK-UHFFFAOYSA-N
SMILESC1COCCN1CC2=CN=C(C=C2)C3=C(NC4=C3C=C(C=C4)C#N)O

Computed by PubChem (NCBI)

Synonyms: 2-Hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile, 1H-Indole-5-carbonitrile, 2-hydroxy-3-(5-(4-morpholinylmethyl)-2-pyridinyl)-, 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile, 2-hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile, Kinome_2945, orb1224464, orb1307560, BLTVBQXJFVRPFK-UHFFFAOYSA-N
Isomers (same molecular formula)
3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one C19H18N4O2
ethyl 2-[(4-cyanoanilino)methyl]-1-methylbenzimidazole-5-carboxylate C19H18N4O2
ethyl 2-[(4-cyanoanilino)methyl]-1-(trideuteriomethyl)benzimidazole-5-carboxylate C19H18N4O2
ethyl 5-(benzylamino)-3-phenyl-1,2,4-triazine-6-carboxylate C19H18N4O2
ethyl 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoate C19H18N4O2
2-[4-[(1E)-1-hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]ethanol C19H18N4O2
2-(3,5-dimethyl-1-phenylpyrazol-4-yl)-3-hydroxy-1,2-dihydroquinazolin-4-one C19H18N4O2
2-[2-[(2-ethylbenzimidazol-1-yl)methyl]benzimidazol-1-yl]acetic acid C19H18N4O2
3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one C19H18N4O2
7-[2-(dimethylamino)ethylamino]indolo[2,1-b]quinazoline-6,12-dione C19H18N4O2

Also listed as

AZD1080 Chemat Brand CAS 612487-72-6
AZD1080/ 99.68% (existing batch purity) TargetMol CAS 612487-72-6
AZD1080, 99.16% MedChemExpress CAS 612487-72-6
AZD1080, 98+% Ambeed CAS 612487-72-6