Entecavir

cas: 142217-69-4 — see every product listed under this CAS number, including other names

Entecavir (CAS 142217-69-4) is a chemical reagent available from Chemat. Available pack sizes: on request. Offered by: Chemat Brand.

brandChemat Brand
catalog numberULE231
cas142217-69-4
sizeon request
availability Do potwierdzenia przez Chemat|To be confirmed by Chemat

Available pack sizes

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properties

purityNo data
categoryChemicals
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Entecavir (anhydrous) is guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B. It has a role as an antiviral drug and an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor. It is a primary alcohol, a member of 2-aminopurines, an oxopurine and a secondary alcohol.

Source: ChEBI

Identity
Molecular formulaC12H15N5O3
Molecular weight277.28 g/mol
IUPAC name2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one
InChIKeyQDGZDCVAUDNJFG-FXQIFTODSA-N
SMILESC=C1[C@H](C[C@@H]([C@H]1CO)O)N2C=NC3=C2N=C(NC3=O)N

Computed by PubChem (NCBI)

Synonyms: Entecavir, Baraclude, anhydrous entecavir, Entecavir anhydrous, entecavir (anhydrous), Entecavirum, Entecavir [USAN:INN], Entecavir (INN), Entecavir [INN], Entecavir sodium
Related forms of this compound
2-amino-9-[(1R,3R,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one C12H15N5O3
2-amino-9-[(1S,3S,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one C12H15N5O3
2-amino-9-[(1S,3S,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one C12H15N5O3
2-amino-9-[(1S,3S,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one C12H15N5O3
2-amino-9-[(1R,3S,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one C12H15N5O3
2-amino-9-[(1R,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one C12H15N5O3
Isomers (same molecular formula)
2-amino-5-[[[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino]methyl]-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one C12H15N5O3
N'-hydroxy-6-[3-(3-methyl-1,2-oxazol-5-yl)propoxy]pyridazine-3-carboximidamide C12H15N5O3

Also listed as

Entecavir, 98% Combi-blocks CAS 142217-69-4
Entecavir, >95% (HPLC) TRC CAS 142217-69-4
Entecavir/ 99.72% (existing batch purity) TargetMol CAS 142217-69-4
Entecavir–d2 GLPBio CAS 142217-69-4
Entecavir (BMS200475) GLPBio CAS 142217-69-4
Entecavir 98% Ambeed CAS 142217-69-4
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one, 95+%, 95+% Chemat CAS 142217-69-4
Entecavir, 99.98% MedChemExpress CAS 142217-69-4
Entecavir, 95% Fluorochem CAS 142217-69-4