SN-38 98%

cas: 86639-52-3 — see every product listed under this CAS number, including other names

SN-38 98% (CAS 86639-52-3) is a chemical reagent available from Chemat. Available pack sizes: 100mg, 250mg, 1g, 5g, 10g, 25g, 100g. Offered by: Ambeed.

brandAmbeed
catalog numberA366170-100mg
cas86639-52-3
size100mg
Documents: Safety Data Sheet (MSDS)
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Available pack sizes

brand size price
Ambeed 100mg 147.88 Pln
Ambeed 250mg 186.81 Pln
Ambeed 1g 348.12 Pln
Ambeed 5g 782.00 Pln
Ambeed 10g 1321.56 Pln
Ambeed 25g 3096.00 Pln
Ambeed 100g 12168.44 Pln

properties

purity98%
delivery time 1-2 weeks
ambeed catalog no.A366170
Structural formula: {0} (CAS {1})

SN-38 is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an antineoplastic agent, a drug metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an apoptosis inducer. It is a delta-lactone, a tertiary alcohol, a member of phenols and a pyranoindolizinoquinoline.

Source: ChEBI

Identity
Molecular formulaC22H20N2O5
Molecular weight392.4 g/mol
IUPAC name(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
InChIKeyFJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILESCCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O

Computed by PubChem (NCBI)

Synonyms: 7-Ethyl-10-hydroxycamptothecin, 10-Hydroxy-7-ethylcamptothecin, 7-Ethyl-10-hydroxy-20(S)-camptothecin, 7 Ethyl 10 hydroxycamptothecin, 7-Ethyl-10-hydroxy-camptothecin, 7-10-hydroxycamptothecin, Irinotecan EP Impurity E, Captothecin, 7-ethyl-10-hydroxy-, AvaChem1025, diethyl(dihydroxy)[?]dione
Related forms of this compound
(19S)-19-ethyl-7,19-dihydroxy-10-(2,2,2-trideuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
(19R)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
(19S)-19-ethyl-7,19-dihydroxy-10-(1,1,2,2,2-pentadeuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione C22H20N2O5
Isomers (same molecular formula)
(19S)-10,19-diethyl-19-hydroxy-3-oxido-17-oxa-13-aza-3-azoniapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione C22H20N2O5
methyl 1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate C22H20N2O5
methyl (1R,3R)-2-acetyl-1-(1,3-benzodioxol-5-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate C22H20N2O5
(19S)-5,19-diethyl-8,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione C22H20N2O5
4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione C22H20N2O5

Also listed as

7-Ethyl-10-hydroxycamptothecin, 97% Combi-blocks CAS 86639-52-3
Irinotecan EP Impurity E ((S)-7-Ethyl-10-Hydroxy Camptothecin) Chemat Brand CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin ((S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione) Mikromol CAS 86639-52-3
SN-38, >95% (HPLC) TRC CAS 86639-52-3
SN–38 (NK012) GLPBio CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin Biosynth CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, >98.0%(HPLC) TCI CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, 98% Thermo Scientific (Acros) CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, 98.00% Chemat CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, min. 95 %, 1 g Roth CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, min. 95 %, 5 g Roth CAS 86639-52-3
7-Ethyl-10-hydroxycamptothecin, min. 95 %, 10 g Roth CAS 86639-52-3
SN-38, 99.94% MedChemExpress CAS 86639-52-3
SN-38 (Standard), 99.76% MedChemExpress CAS 86639-52-3
7-Ethyl-10-hydroxy-camptothecin, 98% Fluorochem CAS 86639-52-3