Products 1373423-53-0

CAS 1373423-53-0 appears in our catalog under these names: GSK J4, GSK-J4/ 98.24% (existing batch purity), GSK J4 free base, GSK-J4 98%, Histone Lysine Demethylase I 1PC X 10MG. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 100mg, 2mg, 5mg, 10mg, 25mg, 50mg, 200mg, 1g.

GSK J4
TRC, Biosynth
  • size: 100mg, 1g
  • Variants: 2
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GSK-J4/ 98.24% (existing batch purity)
TargetMol
  • size: 2mg, 5mg, 10mg, 25mg
  • Variants: 7
from 518.63
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GSK J4 free base
GLPBio
  • size: 10mg, 50mg
  • Variants: 2
from 807.66
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GSK-J4 98%
Ambeed
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 147.88
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Histone Lysine Demethylase I 1PC X 10MG
Sigma-Aldrich
  • size: 10MG
  • Variants: 1
from 1080.00
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GSK J4 HCl, 98%, 98%
Chemat
  • size: 1mg, 5mg, 100mg, 250mg
  • Variants: 4
from 122.00
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GSK-J4, 99.45%
MedChemExpress
  • size: 50 mg, 10 mg, 100 mg, 5 mg
  • Variants: 5
from 602.98
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GSK-J4 (Standard)
MedChemExpress
  • size: 25 mg, 100 mg, 50 mg, 5 mg
  • Variants: 5
from 1150.97
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GSK-J4, 98%
Fluorochem
  • size: 100mg, 250mg
  • Variants: 2
from 2236.73
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Structural formula: {0} (CAS {1})

GSK-J4 is a member of the class of aminopyrimidines that is pyrimidine substituted by pyridin-2-yl, 3-ethoxy-3-oxopropylamino, and 1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl groups at positions 2, 4, and 6, respectively. It is an inhibitor of the histone demethylase JMJD3/UTX. It has a role as a ferroptosis inducer, an EC 1.14.11.68 ([histone H3]-trimethyl-L-lysine(27) demethylase) inhibitor, an antineoplastic agent and a prodrug. It is an ethyl ester, a member of pyridines, a benzazepine, an aminopyrimidine, a secondary amino compound and a tertiary amino compound. It is functionally related to a GSK-J1.

Source: ChEBI

Identity
Molecular formulaC24H27N5O2
Molecular weight417.5 g/mol
IUPAC nameethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate
InChIKeyWBKCKEHGXNWYMO-UHFFFAOYSA-N
SMILESCCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=CC=CC=C4CC3

Computed by PubChem (NCBI)

Synonyms: GSK J4 HCl, GSK J4 hydrochloride, GSK-J1 Pro-Drug, GSK-J4 free base, orb1226421, orb1697740, GSK-J4 free base; GSK-J-4; GSK-J 4; GSK-J4
Isomers (same molecular formula)
(7S)-2-(4-phenoxyphenyl)-7-piperidin-4-yl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide C24H27N5O2
ethyl 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate C24H27N5O2