Products 592542-59-1

CAS 592542-59-1 appears in our catalog under these names: Rigosertib, 95%, Rigosertib, Rigosertib/ 97.33% (existing batch purity), Rigosertib-d6, Rigosertib 98%. Offered by: Combi-blocks, TRC, TargetMol, GLPBio, Biosynth. Available pack sizes: 250mg, 100mg, 1g, 500mg, 2mg, 5mg, 10mg, 10mM (in 1ml dmso).

Rigosertib, 95%
Combi-blocks
  • size: 250mg, 100mg, 1g
  • Variants: 3
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Rigosertib
TRC, GLPBio
  • size: 500mg, 10mg, 100mg, 5mg
  • Variants: 6
from 802.98
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Rigosertib/ 97.33% (existing batch purity)
TargetMol
  • size: 2mg, 5mg, 10mg
  • Variants: 3
from 412.42
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Rigosertib-d6
Biosynth
  • size: 50mg, 100mg
  • Variants: 2
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Rigosertib 98%
Ambeed
  • size: 25mg, 50mg, 100mg, 250mg
  • Variants: 4
from 1288.19
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N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine, 98%, 98%
Chemat
  • size: 1mg
  • Variants: 1
from 194.00
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Rigosertib, 99.01%
MedChemExpress
  • size: 10 mg, 5 mg, 100 mg, 50 mg
  • Variants: 4
from 454.37
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Structural formula: {0} (CAS {1})

Rigosertib is an N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine in which the double bond has E-configuration. It is a non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM and exhibits anti-cancer properties. It has a role as an EC 2.7.11.21 (polo kinase) inhibitor, an antineoplastic agent, a microtubule-destabilising agent and an apoptosis inducer. It is a conjugate acid of a rigosertib(1-).

Source: ChEBI

Identity
Molecular formulaC21H25NO8S
Molecular weight451.5 g/mol
IUPAC name2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetic acid
InChIKeyOWBFCJROIKNMGD-BQYQJAHWSA-N
SMILESCOC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O

Computed by PubChem (NCBI)

Synonyms: Rigosertib, rigosertibum, Rigosertib [USAN:INN], Rigosertib [USAN], Rigosertib (USAN), RIGOSERTIB [INN], Rigosertib - API Standards, RIGOSERTIB [WHO-DD], Estybon (proposed trade name), orb1217844