Products 935881-37-1
CAS 935881-37-1 appears in our catalog under these names: AR-42, AR–42 (OSU–HDAC42), AR42/ 99.46% (existing batch purity), AR-42 98%, AR-42, 98%, 98%. Offered by: TRC, GLPBio, TargetMol, Ambeed, Chemat. Available pack sizes: 500mg, 10mg, 25mg, 5mg, 10mM (in 1ml dmso), 50mg, 1mg, 100mg.
AR-42 is a secondary carboxamide resulting from the formal condensation of the carboxy group of (2S)-3-methyl-2-phenylbutanoic acid with the amino group of 4-amino-N-hydroxybenzamide. It is a pan-HDAC inhibitor that was in clinical development for the treatment of hematological malignancies and solid tumours. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 3.5.1.98 (histone deacetylase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzenes and a hydroxamic acid.
Source: ChEBI
| Molecular formula | C18H20N2O3 |
|---|---|
| Molecular weight | 312.4 g/mol |
| IUPAC name | N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide |
| InChIKey | LAMIXXKAWNLXOC-INIZCTEOSA-N |
| SMILES | CC(C)[C@@H](C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO |
Computed by PubChem (NCBI)
Synonyms:
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide, N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide, Rec-2282, N-hydroxy-4-[(2S)-3-methyl-2-phenylbutanamido]benzamide, N-Hydroxy-4-(3-methyl-2-(S)phenyl-butyrylamino)benzamide, (S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)-benzamide, N-hydroxy-4-((2S)-3-methyl-2-phenylbutanamido)benzamide, N-hydroxy-4-(((2S)-3-methyl-2-phenylbutanoyl)amino)benzamide, N-hydroxy-4-{[(2S)-3-methyl-2-phenylbutanoyl]amino}benzamide, orb1222983