(R)-Ruxolitinib (>90%), >95% (HPLC)

cas: 941678-49-5 — see every product listed under this CAS number, including other names

(R)-Ruxolitinib (>90%), >95% (HPLC) (CAS 941678-49-5) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 1mg, 50mg. Offered by: TRC.

brandTRC
catalog numberTRC-R702000-10MG
cas941678-49-5
size10mg
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Available pack sizes

brand size price
TRC 10mg price on request
TRC 1mg price on request
TRC 50mg price on request

properties

purity>95% (HPLC)
delivery timeTo be confirmed by Chemat

Ruxolitinib is a pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. It has a role as an antineoplastic agent and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a nitrile, a member of pyrazoles and a pyrrolopyrimidine.

Source: ChEBI

Identity
Molecular formulaC17H18N6
Molecular weight306.4 g/mol
IUPAC name(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
InChIKeyHFNKQEVNSGCOJV-OAHLLOKOSA-N
SMILESC1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

Computed by PubChem (NCBI)

Synonyms: Ruxolitinib, ruxolitinibum, Oral JAK Inhibitor INCB18424, Ruxolitinib (INCB018424), Jakavi, (R)-ruxolitinib, (R)-Ruxolitinib (>90%), R-Ruxolitinib, Ruxolitinib [INN], Ruxolitinib [USAN:INN]
Related forms of this compound
(3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
3-(2,2,3,3,4,4,5,5-octadeuteriocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
(3R)-3-(2,2,3,3,4,4,5,5-octadeuteriocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
3-(1,2,2,3,3,4,4,5,5-nonadeuteriocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
(3R)-3-(1,2,2,3,3,4,4,5,5-nonadeuteriocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
Isomers (same molecular formula)
1-tert-butyl-3-(1H-indol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine C17H18N6
3-(1-methylindol-5-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine C17H18N6

Also listed as

Ruxolitinib Chemat Brand CAS 941678-49-5
Ruxolitinib (INCB18424) GLPBio CAS 941678-49-5
Ruxolitinib/ 99.7% (existing batch purity) TargetMol CAS 941678-49-5
Ruxolitinib, 98% Thermo Scientific (Acros) CAS 941678-49-5
Ruxolitinib (free base) Chemat CAS 941678-49-5
(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile, 98%, 98% Chemat CAS 941678-49-5
Ruxolitinib, 99.99% MedChemExpress CAS 941678-49-5
Ruxolitinib (Standard), 99.74% MedChemExpress CAS 941678-49-5
Ruxolitinib-d4 Chemat Brand CAS 941678-49-5 (non-labelled)
Ruxolitinib-d4 Hubei YoungXin CAS 941678-49-5(non-labelled)