Ruxolitinib (INCB18424)

cas: 941678-49-5 — see every product listed under this CAS number, including other names

Ruxolitinib (INCB18424) (CAS 941678-49-5) is a chemical reagent available from Chemat. Available pack sizes: 100mg, 25mg, 10mM (in 1ml dmso). Offered by: GLPBio.

brandGLPBio
catalog numberGC14191-100
cas941678-49-5
size100mg
Need more information?

Ask us about this product — we're happy to help.

Available pack sizes

brand size price
GLPBio 100mg 1345.92 Pln
GLPBio 25mg 966.80 Pln
GLPBio 10mM (in 1ml dmso) 639.16 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat

Ruxolitinib is a pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. It has a role as an antineoplastic agent and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a nitrile, a member of pyrazoles and a pyrrolopyrimidine.

Source: ChEBI

Identity
Molecular formulaC17H18N6
Molecular weight306.4 g/mol
IUPAC name(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
InChIKeyHFNKQEVNSGCOJV-OAHLLOKOSA-N
SMILESC1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

Computed by PubChem (NCBI)

Synonyms: Ruxolitinib, ruxolitinibum, Oral JAK Inhibitor INCB18424, Ruxolitinib (INCB018424), Jakavi, (R)-ruxolitinib, (R)-Ruxolitinib (>90%), R-Ruxolitinib, Ruxolitinib [INN], Ruxolitinib [USAN:INN]
Related forms of this compound
(3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
3-(2,2,3,3,4,4,5,5-octadeuteriocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
(3R)-3-(2,2,3,3,4,4,5,5-octadeuteriocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
3-(1,2,2,3,3,4,4,5,5-nonadeuteriocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
(3R)-3-(1,2,2,3,3,4,4,5,5-nonadeuteriocyclopentyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile C17H18N6
Isomers (same molecular formula)
1-tert-butyl-3-(1H-indol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine C17H18N6
3-(1-methylindol-5-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine C17H18N6

Also listed as

Ruxolitinib Chemat Brand CAS 941678-49-5
(R)-Ruxolitinib (>90%), >95% (HPLC) TRC CAS 941678-49-5
Ruxolitinib/ 99.7% (existing batch purity) TargetMol CAS 941678-49-5
Ruxolitinib, 98% Thermo Scientific (Acros) CAS 941678-49-5
Ruxolitinib (free base) Chemat CAS 941678-49-5
Ruxolitinib, 99.99% MedChemExpress CAS 941678-49-5
Ruxolitinib (Standard), 99.74% MedChemExpress CAS 941678-49-5
(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile, 98% Chemat CAS 941678-49-5
Ruxolitinib-d4 Chemat Brand CAS 941678-49-5 (non-labelled)
Ruxolitinib-d4 Hubei YoungXin CAS 941678-49-5(non-labelled)