CAS 941678-49-5 appears in our catalog under these names: Ruxolitinib, (R)-Ruxolitinib (>90%), >95% (HPLC), Ruxolitinib (INCB18424), Ruxolitinib/ 99.7% (existing batch purity), Ruxolitinib, 98%. Offered by: Chemat Brand, Mikromol, TRC, GLPBio, TargetMol. Available pack sizes: on request, 50mg, 10mg, 1mg, 100mg, 25mg, 10mM (in 1ml dmso), 5mg.
Ruxolitinib is a pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. It has a role as an antineoplastic agent and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a nitrile, a member of pyrazoles and a pyrrolopyrimidine.
Source: ChEBI
| Molecular formula | C17H18N6 |
|---|---|
| Molecular weight | 306.4 g/mol |
| IUPAC name | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile |
| InChIKey | HFNKQEVNSGCOJV-OAHLLOKOSA-N |
| SMILES | C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 |
Computed by PubChem (NCBI)