6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide, 97%, 97%

cas: 1254053-43-4 — see every product listed under this CAS number, including other names

6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide, 97%, 97% (CAS 1254053-43-4) is a chemical reagent available from Chemat. Available pack sizes: 1mg, 2mg, 5mg, 50mg, 100mg, 250mg, 1g, 5g. Offered by: Chemat.

brandChemat
catalog numberCh111NMP-1mg
cas1254053-43-4
size1mg
availability 10g
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Available pack sizes

brand size price
Chemat 1mg 122.00 Pln
Chemat 2mg 146.00 Pln
Chemat 5mg 165.20 Pln
Chemat 50mg 227.60 Pln
Chemat 100mg 314.00 Pln
Chemat 250mg 501.20 Pln
Chemat 1g 1082.00 Pln
Chemat 5g 3424.40 Pln

properties

purity97%
delivery time3 weeks
Structural formula: {0} (CAS {1})

Gilteritinib is a member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a primary carboxamide, a monomethoxybenzene, a member of piperidines, an aromatic amine, a member of pyrazines, a N-methylpiperazine, a member of oxanes and a secondary amino compound.

Source: ChEBI

Identity
Molecular formulaC29H44N8O3
Molecular weight552.7 g/mol
IUPAC name6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
InChIKeyGYQYAJJFPNQOOW-UHFFFAOYSA-N
SMILESCCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5

Computed by PubChem (NCBI)

Synonyms: Gilteritinib, gilteritinibum, Gilteritinib HCl, Gilteritinib [USAN:INN], Gilteritinib (Standard), GILTERITINIB [MI], Gilteritinib(ASP2215), Gilteritinib (USAN/INN), GILTERITINIB [INN], GILTERITINIB [USAN]
Related forms of this compound
6-ethyl-3-[3-methoxy-4-[4-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide C29H44N8O3

Also listed as

Gilteritinib Chemat Brand CAS 1254053-43-4
Gilteritinib, >95% (HPLC) TRC CAS 1254053-43-4
Gilteritinib/ 99.72% (existing batch purity) TargetMol CAS 1254053-43-4
Gilteritinib, 98% Thermo Scientific (Acros) CAS 1254053-43-4
Gilteritinib, 99.84% MedChemExpress CAS 1254053-43-4
Gilteritinib (Standard), 99.60% MedChemExpress CAS 1254053-43-4
Gilteritinib, 97% Fluorochem CAS 1254053-43-4