Products 1254053-43-4

CAS 1254053-43-4 appears in our catalog under these names: 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide, 97%, 97%, Gilteritinib, Gilteritinib, >95% (HPLC), Gilteritinib/ 99.72% (existing batch purity), Gilteritinib, 98%. Offered by: Chemat, Chemat Brand, TRC, TargetMol, GLPBio. Available pack sizes: 1mg, 2mg, 5mg, 50mg, 100mg, 250mg, 1g, 5g.

6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide, 97%, 97%
Chemat
  • size: 1mg, 2mg, 5mg, 50mg
  • Variants: 8
from 122.00
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Gilteritinib
Chemat Brand, GLPBio, Biosynth
  • size: on request, 10mg, 100mg, 2mg
  • Variants: 12
from 685.97
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Gilteritinib, >95% (HPLC)
TRC
  • size: 100mg, 10mg, 50mg
  • Variants: 3
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Gilteritinib/ 99.72% (existing batch purity)
TargetMol
  • size: 1g, 1mg, 2mg, 5mg
  • Variants: 9
from 412.42
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Gilteritinib, 98%
Thermo Scientific (Acros)
  • size: 100MG
  • Variants: 1
from 1069.07
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Gilteritinib 97%
Ambeed
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 9
from 147.88
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Gilteritinib, 99.84%
MedChemExpress
  • size: 100 mg, 5 mg, 200 mg, 25 mg
  • Variants: 6
from 598.33
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Gilteritinib (Standard), 99.60%
MedChemExpress
  • size: 100 mg, 50 mg, 25 mg, 5 mg
  • Variants: 5
from 1081.31
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Gilteritinib, 97%
Fluorochem
  • size: 5mg, 50mg, 100mg, 250mg
  • Variants: 5
from 289.50
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Structural formula: {0} (CAS {1})

Gilteritinib is a member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a primary carboxamide, a monomethoxybenzene, a member of piperidines, an aromatic amine, a member of pyrazines, a N-methylpiperazine, a member of oxanes and a secondary amino compound.

Source: ChEBI

Identity
Molecular formulaC29H44N8O3
Molecular weight552.7 g/mol
IUPAC name6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
InChIKeyGYQYAJJFPNQOOW-UHFFFAOYSA-N
SMILESCCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5

Computed by PubChem (NCBI)

Synonyms: Gilteritinib, gilteritinibum, Gilteritinib HCl, Gilteritinib [USAN:INN], Gilteritinib (Standard), GILTERITINIB [MI], Gilteritinib(ASP2215), Gilteritinib (USAN/INN), GILTERITINIB [INN], GILTERITINIB [USAN]
Related forms of this compound
6-ethyl-3-[3-methoxy-4-[4-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide C29H44N8O3