Gilteritinib

cas: 1254053-43-4 — see every product listed under this CAS number, including other names

Gilteritinib (CAS 1254053-43-4) is a chemical reagent available from Chemat. Available pack sizes: on request, 10mg, 100mg, 2mg, 5mg, 10mM (in 1ml dmso), 50mg, 25mg. Offered by: Chemat Brand, GLPBio, Biosynth.

brandChemat Brand
catalog numberULG197001
cas1254053-43-4
sizeon request
availability Do potwierdzenia przez Chemat|To be confirmed by Chemat
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Available pack sizes

brand size price
Chemat Brand on request price on request
GLPBio 10mg 952.76 Pln
GLPBio 100mg 2810.92 Pln
GLPBio 2mg 685.97 Pln
GLPBio 5mg 751.50 Pln
GLPBio 10mM (in 1ml dmso) 826.38 Pln
GLPBio 50mg 2305.42 Pln
Biosynth 100mg price on request
Biosynth 10mg price on request
Biosynth 25mg price on request
Biosynth 50mg price on request
Biosynth 250mg price on request

properties

purityNo data
categoryChemicals
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Gilteritinib is a member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a primary carboxamide, a monomethoxybenzene, a member of piperidines, an aromatic amine, a member of pyrazines, a N-methylpiperazine, a member of oxanes and a secondary amino compound.

Source: ChEBI

Identity
Molecular formulaC29H44N8O3
Molecular weight552.7 g/mol
IUPAC name6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
InChIKeyGYQYAJJFPNQOOW-UHFFFAOYSA-N
SMILESCCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5

Computed by PubChem (NCBI)

Synonyms: Gilteritinib, gilteritinibum, Gilteritinib HCl, Gilteritinib [USAN:INN], Gilteritinib (Standard), GILTERITINIB [MI], Gilteritinib(ASP2215), Gilteritinib (USAN/INN), GILTERITINIB [INN], GILTERITINIB [USAN]
Related forms of this compound
6-ethyl-3-[3-methoxy-4-[4-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide C29H44N8O3

Also listed as

6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide, 97%, 97% Chemat CAS 1254053-43-4
Gilteritinib, >95% (HPLC) TRC CAS 1254053-43-4
Gilteritinib/ 99.72% (existing batch purity) TargetMol CAS 1254053-43-4
Gilteritinib, 98% Thermo Scientific (Acros) CAS 1254053-43-4
Gilteritinib 97% Ambeed CAS 1254053-43-4
Gilteritinib, 99.84% MedChemExpress CAS 1254053-43-4
Gilteritinib (Standard), 99.60% MedChemExpress CAS 1254053-43-4
Gilteritinib, 97% Fluorochem CAS 1254053-43-4