Niraparib, ISO 17034 RM
cas: 1038915-60-4 — see every product listed under this CAS number, including other names
Niraparib, ISO 17034 RM (CAS 1038915-60-4) is a chemical reagent available from Chemat. Available pack sizes: 10mg. Offered by: HPC Standards.
| brand | HPC Standards |
|---|---|
| catalog number | 681850 |
| cas | 1038915-60-4 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| HPC Standards | 10mg | price on request |
properties
| delivery time | TBC |
|---|
Niraparib is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. It has a role as a radiosensitizing agent, an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an apoptosis inducer.
Source: ChEBI
| Molecular formula | C19H20N4O |
|---|---|
| Molecular weight | 320.4 g/mol |
| IUPAC name | 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide |
| InChIKey | PCHKPVIQAHNQLW-CQSZACIVSA-N |
| SMILES | C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N |
Computed by PubChem (NCBI)
Synonyms:
Niraparib, 2-{4-[(3s)-piperidin-3-yl]phenyl}-2h-indazole-7-carboxamide, 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide, niraparibum, 2-(4-((3S)-piperidin-3-yl)phenyl)indazole-7-carboxamide, (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide, Niraparib [USAN], 2-[4-(3S)-3-Piperidinylphenyl]-2H-indazole-7-carboxamide, Niraparib (USAN), 2-[4-[(3S)-3-Piperidyl]phenyl]indazole-7-carboxamide
