Products 163451-81-8
CAS 163451-81-8 appears in our catalog under these names: Leflunomide EP Impurity B (Teriflunomide), A 77-1726, >95% (HPLC), Teriflunomide, >95% (HPLC), (2Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide (Teriflunomide), A–771726. Offered by: Chemat Brand, TRC, Mikromol, GLPBio, TargetMol. Available pack sizes: on request, 10mg, 500mg, 50mg, 100mg, 25mg, 5mg, 10g.
Teriflunomide is an enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis. It has a role as a non-steroidal anti-inflammatory drug, a tyrosine kinase inhibitor, a drug metabolite, a hepatotoxic agent and an EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor. It is a secondary carboxamide, a nitrile, an enol, an enamide, an aromatic amide and a member of (trifluoromethyl)benzenes.
Source: ChEBI
| Molecular formula | C12H9F3N2O2 |
|---|---|
| Molecular weight | 270.21 g/mol |
| IUPAC name | (Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide |
| InChIKey | UTNUDOFZCWSZMS-YFHOEESVSA-N |
| SMILES | C/C(=C(\C#N)/C(=O)NC1=CC=C(C=C1)C(F)(F)F)/O |
Computed by PubChem (NCBI)
Synonyms:
Teriflunomide, Aubagio, Flucyamide, (Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide, teriflunomida, teriflunomidum, (Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide, N-(4-Trifluoromethylphenyl)-2-cyano-2-hydroxycrotonamide, 2-hydroxyethylidene-cyanoacetic acid-4-trifluoromethyl anilide