Products 219911-35-0
CAS 219911-35-0 appears in our catalog under these names: MPEP Hydrochloride, >95% (HPLC), MPEP hydrochloride/ 99.75% (existing batch purity), MPEP Hydrochloride, 2-Methyl-6-(phenylethynyl)pyridine HCl, MPEP HCl 98%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 250mg, 25mg, 50mg, 10mg, 100mg, 5mg, 10mM (in 1ml water), 500mg.
2-methyl-6-(phenylethynyl)pyridine hydrochloride is a hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as an anxiolytic drug and a metabotropic glutamate receptor antagonist. It contains a 2-methyl-6-(phenylethynyl)pyridinium(1+).
Source: ChEBI
| Molecular formula | C14H12ClN |
|---|---|
| Molecular weight | 229.70 g/mol |
| IUPAC name | 2-methyl-6-(2-phenylethynyl)pyridine;hydrochloride |
| InChIKey | PKDHDJBNEKXCBI-UHFFFAOYSA-N |
| SMILES | CC1=NC(=CC=C1)C#CC2=CC=CC=C2.Cl |
Computed by PubChem (NCBI)
Synonyms:
MPEP hydrochloride, 2-methyl-6-(phenylethynyl)pyridine hydrochloride, 6-Methyl-2-(phenylethynyl)pyridine hydrochloride, 2-methyl-6-(phenylethynyl)pyridinium chloride, 6-methyl-2-(phenylethynyl)pyridinium chloride, 6-Methyl-2-(phenylethynyl)pyridine, hydrochloride, Pyridine, 2-methyl-6-(phenylethynyl)-, hydrochloride, Pyridine, 6-methyl-2-(phenylethynyl)-, hydrochloride, MPEP HCl, MPEP (Hydrochloride)