Products 808118-40-3

CAS 808118-40-3 appears in our catalog under these names: FG-4592, 95%, Roxadustat, N-((4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl)glycine, >95% (HPLC), Roxadustat/ 99.94% (existing batch purity), FG–4592 (ASP1517). Offered by: Combi-blocks, Chemat Brand, Hubei YoungXin, TRC, TargetMol. Available pack sizes: 1g, 100mg, 5g, 250mg, on request, 10mg, 25mg, 50mg.

FG-4592, 95%
Combi-blocks
  • size: 1g, 100mg, 5g, 250mg
  • Variants: 4
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Roxadustat
Chemat Brand, Hubei YoungXin, Biosynth
  • size: on request, 10mg, 25mg, 50mg
  • Variants: 11
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N-((4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl)glycine, >95% (HPLC)
TRC
  • size: 10mg, 250mg, 50mg
  • Variants: 3
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Roxadustat/ 99.94% (existing batch purity)
TargetMol
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 6
from 386.15
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FG–4592 (ASP1517)
GLPBio
  • size: 10mg, 100mg, 200mg, 10mM (in 1ml dmso)
  • Variants: 6
from 583.00
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Roxadustat, 99.92%
MedChemExpress
  • size: 500 mg, 100 mg, 50 mg, 10 mg
  • Variants: 8
from 301.12
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Roxadustat, min. 95 %, 500 mg
Roth
  • size: 500mg
  • Variants: 1
from 1222.38
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Roxadustat, min. 95 %, 1 g
Roth
  • size: 1g
  • Variants: 1
from 1835.93
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Roxadustat, min. 95 %, 2 g
Roth
  • size: 2g
  • Variants: 1
from 2874.24
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Roxadustat (Standard)
MedChemExpress
  • size: 25 mg, 50 mg, 100 mg, 5 mg
  • Variants: 5
from 575.11
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Structural formula: {0} (CAS {1})

Roxadustat is an N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH). It has a role as an EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor and an EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor. It is a N-acylglycine, a member of isoquinolines and an aromatic ether.

Source: ChEBI

Identity
Molecular formulaC19H16N2O5
Molecular weight352.3 g/mol
IUPAC name2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
InChIKeyYOZBGTLTNGAVFU-UHFFFAOYSA-N
SMILESCC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3

Computed by PubChem (NCBI)

Synonyms: Roxadustat, Evrenzo, roxadustatum, (((4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl)amino)acetic acid, N-[(4-hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine, 2-((4-hydroxy-1-methyl-7-(phenoxy)isoquinoline-3-carbonyl)amino)acetic acid, 2-[[4-hydroxy-1-methyl-7-(phenoxy)isoquinoline-3-carbonyl]amino]acetic acid, N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine, Roxadustat (FG-4592), 2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
Related forms of this compound
2-[[4-hydroxy-1-methyl-7-(2,3,4,5,6-pentadeuteriophenoxy)isoquinoline-3-carbonyl]amino]acetic acid C19H16N2O5
Isomers (same molecular formula)
2-[(1-benzyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]acetic acid C19H16N2O5
2-[(1a-methyl-6-oxo-3-phenoxy-1H-indeno[1,2-b]azirine-6a-carbonyl)amino]acetic acid C19H16N2O5
methyl 2-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]acetate C19H16N2O5
2-[(4-hydroxy-1-methyl-6-phenoxyisoquinoline-3-carbonyl)amino]acetic acid C19H16N2O5