(+)-Bicuculline - Bio-X â„¢

cas: 485-49-4 — see every product listed under this CAS number, including other names

(+)-Bicuculline - Bio-X â„¢ (CAS 485-49-4) is a chemical reagent available from Chemat. Available pack sizes: 50mg. Offered by: Biosynth.

brandBiosynth
catalog numberBB164251-50mg
cas485-49-4
size50mg
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properties

categoryLife Sciences
sub-category 1Ligands
sub-category 2Ion Channels
purityNo data
delivery time1-2 weeks
Structural formula: {0} (CAS {1})

Bicuculline is a benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. It has a role as a GABAA receptor antagonist, an agrochemical, a central nervous system stimulant, a GABA-gated chloride channel antagonist and a neurotoxin. It is a benzylisoquinoline alkaloid, an isoquinoline alkaloid and a member of isoquinolines.

Source: ChEBI

Identity
Molecular formulaC20H17NO6
Molecular weight367.4 g/mol
IUPAC name(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
InChIKeyIYGYMKDQCDOMRE-ZWKOTPCHSA-N
SMILESCN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3

Computed by PubChem (NCBI)

Synonyms: bicuculline, d-Bicuculline, Bicculine, Bicucullin, (+)-Bicuculline, Bicuculline (+), D-Bic uculline, bicuculline-(+), IYGYMKDQCDOMRE-ZWKOTPCHSA-N, Bicuculline,(+)
Isomers (same molecular formula)
12-hydroxy-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-23-one C20H17NO6
(2S)-2-[[2-(4-methyl-2-oxochromen-7-yl)oxyacetyl]amino]-2-phenylacetic acid C20H17NO6
methyl 1-(acetyloxymethyl)-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate C20H17NO6
(2S)-2-(1,3-dioxoisoindol-2-yl)-5-oxo-5-phenylmethoxypentanoic acid C20H17NO6
9-acetyl-9-amino-6,7,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione C20H17NO6
6-methylspiro[7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5,7'-9H-[1,3]dioxolo[4,5-h]isochromene]-6'-one C20H17NO6
21-hydroxy-16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(21),2,4(8),9,15(20),16,18-heptaen-14-one C20H17NO6
(5R,8'R)-8'-hydroxy-6-methylspiro[7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5,7'-8H-cyclopenta[g][1,3]benzodioxole]-6'-one C20H17NO6

Also listed as

Bicuculline, >95% (HPLC) TRC CAS 485-49-4
Bicuculline LoGiCal CAS 485-49-4
(+)–Bicuculline GLPBio CAS 485-49-4
Bicuculline/ 99.99% TargetMol CAS 485-49-4
(+)-Bicuculline Biosynth CAS 485-49-4
(+)-Bicuculline, >98.0%(HPLC)(T) TCI CAS 485-49-4
Bicuculline, 99.97% MedChemExpress CAS 485-49-4
Bicuculline (Standard) MedChemExpress CAS 485-49-4
(+)-Bicuculline, BioScience Grade, 50 mg Roth CAS 485-49-4
(+)-BICUCULLINE, 98% Fluorochem CAS 485-49-4
(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 99% Chemat CAS 485-49-4