(+)-Bicuculline

cas: 485-49-4 — see every product listed under this CAS number, including other names

(+)-Bicuculline (CAS 485-49-4) is a chemical reagent available from Chemat. Available pack sizes: 500mg, 1000mg, 25mg, 5g, 2000mg, 5000mg, 10000mg, 100MG. Offered by: Biosynth, Chemat, Sigma-Aldrich.

brandBiosynth
catalog numberFB18590-500mg
cas485-49-4
size500mg
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Available pack sizes

brand size price
Biosynth 500mg price on request
Biosynth 1000mg price on request
Chemat 25mg 785.34 Pln
Chemat 500mg 3488.29 Pln
Chemat 5g 12269.43 Pln
Biosynth 2000mg price on request
Biosynth 5000mg price on request
Biosynth 10000mg price on request
Sigma-Aldrich 100MG 478.00 Pln
Sigma-Aldrich 25MG 422.00 Pln
Sigma-Aldrich 500MG 1810.00 Pln

properties

categoryNatural Products
sub-category 1Alkaloids
purityNo data
delivery time1-2 weeks
Structural formula: {0} (CAS {1})

Bicuculline is a benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. It has a role as a GABAA receptor antagonist, an agrochemical, a central nervous system stimulant, a GABA-gated chloride channel antagonist and a neurotoxin. It is a benzylisoquinoline alkaloid, an isoquinoline alkaloid and a member of isoquinolines.

Source: ChEBI

Identity
Molecular formulaC20H17NO6
Molecular weight367.4 g/mol
IUPAC name(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
InChIKeyIYGYMKDQCDOMRE-ZWKOTPCHSA-N
SMILESCN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3

Computed by PubChem (NCBI)

Synonyms: bicuculline, d-Bicuculline, Bicculine, Bicucullin, (+)-Bicuculline, Bicuculline (+), D-Bic uculline, bicuculline-(+), IYGYMKDQCDOMRE-ZWKOTPCHSA-N, Bicuculline,(+)
Isomers (same molecular formula)
12-hydroxy-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-23-one C20H17NO6
(2S)-2-[[2-(4-methyl-2-oxochromen-7-yl)oxyacetyl]amino]-2-phenylacetic acid C20H17NO6
methyl 1-(acetyloxymethyl)-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate C20H17NO6

Also listed as

Bicuculline, >95% (HPLC) TRC CAS 485-49-4
Bicuculline LoGiCal CAS 485-49-4
(+)–Bicuculline GLPBio CAS 485-49-4
Bicuculline/ 99.99% TargetMol CAS 485-49-4
(+)-Bicuculline - Bio-X â„¢ Biosynth CAS 485-49-4
(+)-Bicuculline, >98.0%(HPLC)(T) TCI CAS 485-49-4
(6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 99%, 99% Chemat CAS 485-49-4
Bicuculline, 99.97% MedChemExpress CAS 485-49-4
Bicuculline (Standard) MedChemExpress CAS 485-49-4
(+)-Bicuculline, BioScience Grade, 50 mg Roth CAS 485-49-4
(+)-BICUCULLINE, 98% Fluorochem CAS 485-49-4