Products 4291-63-8

CAS 4291-63-8 appears in our catalog under these names: Cladribine, Cladribine, >95% (HPLC), Cladribine/ 99.87% (existing batch purity), Cladribine, >98.0%(HPLC), Cladribine - Bio-X â„¢. Offered by: Chemat Brand, TRC, Mikromol, TargetMol, GLPBio. Available pack sizes: on request, 100mg, 10mg, 50mg, 250mg, 5mg, 200mg, 10mM (in 1ml dmso).

Cladribine
Chemat Brand, Mikromol, GLPBio
  • size: on request, 250mg, 10mg, 100mg
  • Variants: 11
from 531.51
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Cladribine, >95% (HPLC)
TRC
  • size: 100mg, 10mg, 50mg
  • Variants: 3
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Cladribine/ 99.87% (existing batch purity)
TargetMol
  • size: 5mg, 10mg, 50mg, 100mg
  • Variants: 5
from 412.42
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Cladribine, >98.0%(HPLC)
TCI
  • size: 50mg
  • Variants: 1
from 206.86
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Cladribine - Bio-X â„¢
Biosynth
  • size: 10mg
  • Variants: 1
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2-CHLORO-2'-DEOXYADENOSINE
Sigma-Aldrich
  • size: 10MG, 25MG
  • Variants: 2
from 1370.00
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2-Chloro-2′-deoxyadenosine 1PC X 10MG
Sigma-Aldrich
  • size: 10MG
  • Variants: 1
from 312.00
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Cladribine, BioScience Grade, 10 mg
Roth
  • size: 10mg
  • Variants: 1
from 514.44
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Cladribine, 99.96%
MedChemExpress
  • size: 10mM/1mL, 50 mg, 100 mg, 10 mg
  • Variants: 5
from 319.69
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Cladribine (Standard)
MedChemExpress
  • size: 5 mg, 25 mg, 10 mg, 50 mg
  • Variants: 5
from 542.60
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2-Chloro-2'-deoxyadenosine, 98%
Fluorochem
  • size: 100mg, 250mg, 1g, 5g
  • Variants: 5
from 258.26
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Cladribine, 98%
Ambeed
  • size: 1mg, 10mg, 100mg, 250mg
  • Variants: 6
from 136.75
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Structural formula: {0} (CAS {1})

Cladribine is 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. It has a role as an antineoplastic agent and an immunosuppressive agent. It is a purine 2'-deoxyribonucleoside and an organochlorine compound.

Source: ChEBI

Identity
Molecular formulaC10H12ClN5O3
Molecular weight285.69 g/mol
IUPAC name(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
InChIKeyPTOAARAWEBMLNO-KVQBGUIXSA-N
SMILESC1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O

Computed by PubChem (NCBI)

Synonyms: Cladribine, 2-Chloro-2'-deoxyadenosine, Leustatin, 2-Chlorodeoxyadenosine, 2-CdA, Chlorodeoxyadenosine, Litak, CldAdo, 2-Chloro-2'-deoxy-beta-adenosine, cladribina
Related forms of this compound
(2R,3S,5S)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3
Isomers (same molecular formula)
(2R,3S,5S)-5-(2-amino-6-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3
(2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol C10H12ClN5O3
(2S,3S,4R,5R)-2-(6-aminopurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol C10H12ClN5O3
2-[(2-amino-6-chloropurin-9-yl)methoxy]ethyl acetate C10H12ClN5O3
(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-chloro-2-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3
(2R,3S,5R)-5-(6-amino-8-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3
5-(2-amino-6-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3
(2R,3R,5S)-2-(2-amino-6-chloropurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3
(2R,3R,5S)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol C10H12ClN5O3